Gut microbiota and short chain fatty acids: implications in glucose homeostasis

P Portincasa, L Bonfrate, M Vacca… - International journal of …, 2022 - mdpi.com
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with …

Intestinal barrier and permeability in health, obesity and NAFLD

P Portincasa, L Bonfrate, M Khalil, MD Angelis… - Biomedicines, 2021 - mdpi.com
The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Manipulating rumen microbiome and fermentation through interventions during early life: a review

DR Yáñez-Ruiz, L Abecia, CJ Newbold - Frontiers in microbiology, 2015 - frontiersin.org
The nutritional manipulations of the rumen microbiome to enhance productivity and health
are rather limited by the resilience of the ecosystem once established in the mature rumen …

[HTML][HTML] Lysozymes in the animal kingdom

L Callewaert, CW Michiels - Journal of biosciences, 2010 - Springer
Abstract Lysozymes (EC 3.2. 1.17) are hydrolytic enzymes, characterized by their ability to
cleave the β-(1, 4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine …

[HTML][HTML] Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?

P Portincasa, M Khalil, A Graziani, G Frühbeck… - European Journal of …, 2024 - Elsevier
The prevalence of overweight, obesity, type 2 diabetes, metabolic syndrome and steatotic
liver disease is rapidly increasing worldwide with a huge economic burden in terms of …

Immunomodulation by helminth parasites: defining mechanisms and mediators

HJ McSorley, JP Hewitson, RM Maizels - International journal for …, 2013 - Elsevier
Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota

V Liévin-Le Moal, AL Servin - Clinical microbiology reviews, 2006 - Am Soc Microbiol
The intestinal tract is a complex ecosystem that combines resident microbiota and the cells
of various phenotypes with complex metabolic activities that line the epithelial wall. The …

Postnatal innate immune development: from birth to adulthood

A Georgountzou, NG Papadopoulos - Frontiers in immunology, 2017 - frontiersin.org
It is well established that adaptive immune responses are deficient in early life, contributing
to increased mortality and morbidity. The developmental trajectories of different components …

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

IG Boneca, O Dussurget, D Cabanes… - Proceedings of the …, 2007 - National Acad Sciences
Listeria monocytogenes is a human intracellular pathogen that is able to survive in the
gastrointestinal environment and replicate in macrophages, thus bypassing the early innate …

Recent advances in the digestive, metabolic and therapeutic effects of farnesoid X receptor and fibroblast growth factor 19: from cholesterol to bile acid signaling

A Di Ciaula, L Bonfrate, J Baj, M Khalil, G Garruti… - Nutrients, 2022 - mdpi.com
Bile acids (BA) are amphiphilic molecules synthesized in the liver (primary BA) starting from
cholesterol. In the small intestine, BA act as strong detergents for emulsification …