This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …

The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …

Mechanochemistry deals with reactions induced by the input of mechanical energy–for
example by impacts within a vibratory ball mill. The technique has a long history with …

Solid-state mechanochemical grinding is important for promoting cocrystal formation,
particularly in the design of new solids in the pharmaceutical industry. Pharmaceutical …

Drug-drug cocrystals have received growing attention in pharmaceutical industry for the
ability to present a strategy for the development of fixed-dose combination drugs. In this …

The stability of different theophylline cocrystals under milling conditions was investigated by
competitive cocrystal reactions. To determine the most stable cocrystal form under milling …

Two new cocrystals of theophylline were prepared by liquid assisted grinding. While
compound 1 (theophylline: 4-aminosalicylic acid 2: 1) was characterized by single crystal X …

Caffeine–oxalic acid cocrystal, widely reported to be stable under high humidity, dissociated
in the presence of numerous pharmaceutical excipients. In cocrystal–excipient binary …

The driving forces triggering the formation of co‐crystals under milling conditions were
investigated by using a set of multicomponent competitive milling reactions. In these …