Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
Pharmaceutical cocrystals: along the path to improved medicines
NK Duggirala, ML Perry, Ö Almarsson… - Chemical …, 2016 - pubs.rsc.org
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …
from crystal engineers and pharmaceutical scientists in the past decade and are now an …
Crystalline multicomponent solids: An alternative for addressing the hygroscopicity issue in pharmaceutical materials
TS Thakur, R Thakuria - Crystal Growth & Design, 2020 - ACS Publications
The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …
change in relative humidity during processing, storage, and transportation can cause …
[HTML][HTML] Introductory Lecture: Mechanochemistry, a versatile synthesis strategy for new materials
W Jones, MD Eddleston - Faraday discussions, 2014 - pubs.rsc.org
Mechanochemistry deals with reactions induced by the input of mechanical energy–for
example by impacts within a vibratory ball mill. The technique has a long history with …
example by impacts within a vibratory ball mill. The technique has a long history with …
Mechanochemical approaches to pharmaceutical cocrystal formation and stability analysis
SY Lin - Current pharmaceutical design, 2016 - ingentaconnect.com
Solid-state mechanochemical grinding is important for promoting cocrystal formation,
particularly in the design of new solids in the pharmaceutical industry. Pharmaceutical …
particularly in the design of new solids in the pharmaceutical industry. Pharmaceutical …
Drug-drug cocrystals of theophylline with quercetin
L Wang, S Li, X Xu, X Xu, Q Wang, D Li… - Journal of Drug Delivery …, 2022 - Elsevier
Drug-drug cocrystals have received growing attention in pharmaceutical industry for the
ability to present a strategy for the development of fixed-dose combination drugs. In this …
ability to present a strategy for the development of fixed-dose combination drugs. In this …
Supply and demand in the ball mill: competitive cocrystal reactions
F Fischer, D Lubjuhn, S Greiser… - Crystal Growth & …, 2016 - ACS Publications
The stability of different theophylline cocrystals under milling conditions was investigated by
competitive cocrystal reactions. To determine the most stable cocrystal form under milling …
competitive cocrystal reactions. To determine the most stable cocrystal form under milling …
X-ray and NMR crystallography studies of novel theophylline cocrystals prepared by liquid assisted grinding
Two new cocrystals of theophylline were prepared by liquid assisted grinding. While
compound 1 (theophylline: 4-aminosalicylic acid 2: 1) was characterized by single crystal X …
compound 1 (theophylline: 4-aminosalicylic acid 2: 1) was characterized by single crystal X …
Mechanistic insight into caffeine–oxalic cocrystal dissociation in formulations: Role of excipients
NK Duggirala, A Vyas, JF Krzyzaniak… - Molecular …, 2017 - ACS Publications
Caffeine–oxalic acid cocrystal, widely reported to be stable under high humidity, dissociated
in the presence of numerous pharmaceutical excipients. In cocrystal–excipient binary …
in the presence of numerous pharmaceutical excipients. In cocrystal–excipient binary …
Survival of the Fittest: Competitive Co‐crystal Reactions in the Ball Mill
F Fischer, M Joester, K Rademann… - … –A European Journal, 2015 - Wiley Online Library
The driving forces triggering the formation of co‐crystals under milling conditions were
investigated by using a set of multicomponent competitive milling reactions. In these …
investigated by using a set of multicomponent competitive milling reactions. In these …