Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features
PAM Michels, O Villafraz, E Pineda, MB Alencar… - Experimental …, 2021 - Elsevier
The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …
Regulatory functions of hypoxia in host–parasite interactions: a focus on enteric, tissue, and blood protozoa
Body tissues are subjected to various oxygenic gradients and fluctuations and hence can
become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional …
become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional …
Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi
Although the genome of Trypanosoma cruzi, the causative agent of Chagas disease, was
first made available in 2005, with additional strains reported later, the intrinsic genome …
first made available in 2005, with additional strains reported later, the intrinsic genome …
Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection
Trypanosoma cruzi, the protozoan that causes Chagas disease, has a complex life cycle
involving several morphologically and biochemically distinct stages that establish intricate …
involving several morphologically and biochemically distinct stages that establish intricate …
Transcriptomic analysis of N-terminal mutated Trypanosoma cruzi UBP1 knockdown underlines the importance of this RNA-binding protein in parasite development
KB Sabalette, VA Campo… - PLOS Neglected …, 2024 - journals.plos.org
Background During its life cycle, the human pathogen Trypanosoma cruzi must quickly
adapt to different environments, in which the variation in the gene expression of the …
adapt to different environments, in which the variation in the gene expression of the …
H2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host …
JN Rosón, MO Vitarelli, HM Costa-Silva… - PLoS …, 2022 - journals.plos.org
Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …
Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations
DA Lima, LO Gonçalves, JL Reis-Cunha… - Parasites & …, 2023 - Springer
Background Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a serious
public health concern in Latin America. Nifurtimox and benznidazole (BZ), the only two …
public health concern in Latin America. Nifurtimox and benznidazole (BZ), the only two …
Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified …
Neolignan licarin A (1) was isolated from leaves of Nectandra oppositifolia (Lauraceae) and
displayed activity against trypomastigote forms of the etiologic agent of American …
displayed activity against trypomastigote forms of the etiologic agent of American …
Modulation of Virulence Factors during Trypanosoma cruzi Differentiation
Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. This
protozoan developed several mechanisms to infect, propagate, and survive in different …
protozoan developed several mechanisms to infect, propagate, and survive in different …
Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms
Trypanosoma cruzi alternates between replicative and nonreplicative life forms,
accompanied by a shift in global transcription levels and by changes in the nuclear …
accompanied by a shift in global transcription levels and by changes in the nuclear …