AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …

Viruses can induce apoptosis of infected cells either directly, to assist virus dissemination, or
by inadvertently triggering cellular sensors that initiate cell death. Cellular checkpoints that …

Chemokine receptors are essential for triggering chemotaxis to immune cells; however, a
number of them can also mediate death when engaged by nonchemokine ligands. When …

Activation-induced death of T cells regulates immune responses and is considered to
involve apoptosis induced by ligation of Fas and TNF receptors. The role of other receptors …

Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also
involved in the pathogenesis of many human diseases including human immunodeficiency …

Infection of T cells with HIV-1 induces apoptosis and modulates apoptosis regulatory
molecules. Similar effects occur following treatment of cells with individual HIV-1 encoded …

Signals orchestrating productive CD4+ T‐cell responses are well documented; however, the
regulation of contraction of CD4+ T‐cell effector populations following the resolution of …

Recent methodological advances allow the analysis of clonal composition within T-cell
subsets. Here, Mala Maini and colleagues review the available data on clonality in acute …

Apoptosis of uninfected bystander T cells contributes to T-cell depletion during human
immunodeficiency virus type 1 (HIV-1) infection. HIV-1 envelope/receptor interactions and …

Death signaling by Fas and TNF receptors plays a major role in the control of activated
mature T cells. However, the nature of the death receptors, which may be used by the …