Introduction: Allergy results from an aberrant Type 2 inflammatory response, triggered by a
wide range of environmental antigens (allergens) that lead to various immune responses …

At the turn of the last century, the emerging field of medical oncology chose a cytotoxic
approach to cancer therapy over an immune-centered approach at a time when evidence in …

Abstract Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 …

Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …

Sepsis remains a major problem for human health worldwide, thereby manifesting high rates
of morbidity and mortality. Sepsis, once understood as a monophasic sustained …

Asthma is a high-prevalence disease, still accounting for mortality and high direct and
indirect costs. It is now recognized that, despite the implementation of guidelines, a large …

Background Eosinophilic esophagitis (EoE) is a chronic allergic disease with limited
treatment options. Objective We evaluated QAX576, an mAb against IL-13, in the treatment …

Food allergy is a common condition for which the only currently approved treatments are
avoidance of the allergenic food and administration of emergency medications on accidental …

Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by
either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic …

High-throughput drug combination screening provides a systematic strategy to discover
unexpected combinatorial synergies in pre-clinical cell models. However, phenotypic …