5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Migraine is a neurovascular disorder that involves activation of the trigeminovascular system
and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP) …

Cannabinoids, including those found in cannabis, have shown promise as potential
therapeutics for numerous health issues, including pathological pain and diseases that …

Neuropathic pain is a devastating disease that affects millions of people worldwide.
Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of …

Serotonin [5-hydroxytryptamine (5-HT)] released from mast cells or platelets in peripheral
tissues is one of the important inflammatory mediators in pain and hyperalgesia. The …

Although 5-HT has been implicated in cholestatic itch and antinociception, two common
phenomena in patients with cholestatic disease, the roles of 5-HT receptor subtypes are …

Peripheral serotonin (5HT) has been implicated in migraine and temporomandibular pain
disorders in humans and animal models and yet the mechanism (s) by which 5HT evokes …

Cannabidiol (CBD) is the most abundant non-psychoactive component found in plants of the
genus Cannabis. Its analgesic effect for the treatment of neuropathy has been widely …

The role of 5-hydroxytryptamine (5-HT) 4, 5-HT6, and 5-HT7 receptors in formalin-induced
secondary allodynia and hyperalgesia in rats was assessed. Formalin produced acute …

The antinociceptive role of spinal 5-HT 5A receptors in rat models of pain along with their
expression was evaluated in the spinal cord and dorsal root ganglion (DRG). Nociception …