Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers

B Khavari, MJ Cairns - Cells, 2020 - mdpi.com
Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms
that causes very significant disability in young people. While schizophrenia has a strong …

Neurobiological perspective of 22q11. 2 deletion syndrome

JR Zinkstok, E Boot, AS Bassett, N Hiroi… - The Lancet …, 2019 - thelancet.com
Summary 22q11. 2 deletion syndrome is characterised by a well defined microdeletion that
is associated with a high risk of neuropsychiatric disorders, including intellectual disability …

Sperm microRNAs confer depression susceptibility to offspring

Y Wang, ZP Chen, H Hu, J Lei, Z Zhou, B Yao… - Science …, 2021 - science.org
Evidence that offspring traits can be shaped by parental life experiences in an epigenetically
inherited manner paves a way for understanding the etiology of depression. Here, we show …

Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia

I Khadimallah, R Jenni, JH Cabungcal, M Cleusix… - Molecular …, 2022 - nature.com
Early detection and intervention in schizophrenia requires mechanism-based biomarkers
that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of …

Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer's disease

Z Shi, K Zhang, H Zhou, L Jiang, B Xie, R Wang… - Aging cell, 2020 - Wiley Online Library
Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some
tumor suppressors, including miR‐34c, are decreased in cancer but increased in AD. The …

LSD1/KDM1A, a gate-keeper of cancer stemness and a promising therapeutic target

P Karakaidos, J Verigos, A Magklara - Cancers, 2019 - mdpi.com
A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway

Y Li, J Wang, S Chen, P Wu, S Xu, C Wang… - Stem Cell Research & …, 2020 - Springer
Background We have previously verified the beneficial effects of exosomes from endothelial
progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in …

RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment

E Benito, C Kerimoglu, B Ramachandran… - Cell Reports, 2018 - cell.com
Physical exercise in combination with cognitive training is known to enhance synaptic
plasticity, learning, and memory and lower the risk for various complex diseases including …

The significant role of microRNAs in gliomas angiogenesis: a particular focus on molecular mechanisms and opportunities for clinical application

A Mafi, R Mannani, S Khalilollah, N Hedayati… - Cellular and Molecular …, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs with only 20–22 nucleic acids that inhibit gene
transcription and translation by binding to mRNA. MiRNAs have a diverse set of target genes …

Dysregulation of mi RNA and its potential therapeutic application in schizophrenia

T Cao, XC Zhen - CNS neuroscience & therapeutics, 2018 - Wiley Online Library
Although it is generally believed that genetic and developmental factors play critical roles in
pathogenesis of schizophrenia, however, the precise etiological mechanism of …