Single-molecule detection has long relied on fluorescent labeling with high quantum-yield
fluorophores. Plasmon-enhanced detection circumvents the need for labeling by allowing …

MicroRNAs (miRNAs) are a series of promising molecules that could regulate gene
expression, while its expression level and type are strictly related to the early diagnosis …

Existing methods for RNA diagnostics, such as reverse transcription PCR (RT-PCR), mainly
rely on nucleic acid amplification (NAA) and RT processes, which are known to introduce …

While nanoscale quantum emitters are effective tags for measuring biomolecular
interactions, their utilities for applications that demand single-unit observations are limited by …

The specificity and simplicity of the Watson–Crick base pair interactions make DNA one of
the most versatile construction materials for creating nanoscale structures and devices …

MicroRNAs (miRNAs) are single-stranded non-coding short ribonucleic acid sequences that
take part in many cellular and biological processes. Recent studies have shown that altered …

Specific detection of tumor-derived EVs (tEVs) in plasma is complicated by nontumor EVs
and non-EV particles. To accurately identify tEVs and profile their surface protein expression …

MicroRNAs and other small oligonucleotides in biofluids are promising disease biomarkers,
yet conventional assays require complex processing steps that are unsuitable for point-of …

Detecting small sequences of RNA in biological samples such as microRNA or viral RNA
demands highly sensitive and specific methods. Here, a reconfigurable DNA origami …

The in vitro detection of low abundance biomolecules via nonenzymatic signal amplification
is an attractive strategy. However, it remains a challenge to monitor targets of interest in situ …