Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …

RIPK1 kinase has emerged as a promising therapeutic target for the treatment of a wide
range of human neurodegenerative, autoimmune, and inflammatory diseases. This was …

Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders.
However, it is unclear how aging interacts with genetic predispositions to promote …

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting
protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like …

Protein ubiquitination is involved in virtually all cellular processes. Enrichment strategies
employing antibodies targeting ubiquitin-derived diGly remnants combined with mass …

Programmed cell death (PCD) has been a major area of constantly growing interest over the
last three decades. Originally, apoptosis was considered the only mechanistic pathway for …