[HTML][HTML] Free fatty acid receptors in health and disease
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
Dietary fiber and SCFAs in the regulation of mucosal immunity
Gut bacterial metabolites such as short-chain fatty acids (SCFAs) have important effects on
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity
Recent studies in both mice and humans have suggested that gut microbiota could
modulate tumor responsiveness to chemo-or immunotherapies. However, the underlying …
modulate tumor responsiveness to chemo-or immunotherapies. However, the underlying …
Organoids in immunological research
YE Bar-Ephraim, K Kretzschmar… - Nature Reviews …, 2020 - nature.com
Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …
immune system has been gathered from animal models and co-cultures with cell lines …
Short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders
Background Butyrate, propionate and acetate are short chain fatty acids (SCFA), important
for maintaining a healthy colon and are considered as protective in colorectal …
for maintaining a healthy colon and are considered as protective in colorectal …
Deficiency of prebiotic fiber and insufficient signaling through gut metabolite-sensing receptors leads to cardiovascular disease
DM Kaye, WA Shihata, HA Jama, K Tsyganov… - Circulation, 2020 - Am Heart Assoc
Background: High blood pressure (BP) continues to be a major, poorly controlled but
modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet …
modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet …
Conditioning of the immune system by the microbiome
DB Graham, RJ Xavier - Trends in Immunology, 2023 - cell.com
The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …
Metabolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity
E Chun, S Lavoie, D Fonseca-Pereira, S Bae… - Immunity, 2019 - cell.com
Group 3 innate lymphoid cells (ILC3s) sense environmental signals that are critical for gut
homeostasis and host defense. However, the metabolite-sensing G-protein-coupled …
homeostasis and host defense. However, the metabolite-sensing G-protein-coupled …
Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors
The gut microbiota modulates immune processes both locally and systemically. This
includes whether and how the immune system reacts to emerging tumours, whether …
includes whether and how the immune system reacts to emerging tumours, whether …
Role of gut microbiota and their metabolites on atherosclerosis, hypertension and human blood platelet function: a review
AK Duttaroy - Nutrients, 2021 - mdpi.com
Emerging data have demonstrated a strong association between the gut microbiota and the
development of cardiovascular disease (CVD) risk factors such as atherosclerosis …
development of cardiovascular disease (CVD) risk factors such as atherosclerosis …