The Trk family of receptors play a wide variety of roles in physiological and disease
processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in …

Insulin resistance is a key pathological feature of type 2 diabetes and is characterized by
defects in signaling by the insulin receptor (IR) protein tyrosine kinase. The inhibition of …

Our research has proven that the inhibitory activity of the serine protease inhibitor
neuroserpin (NS) is impaired because of its oxidation deactivation in glaucoma. Using …

Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …

Abstract The APP-PS1ΔE9 mouse model of Alzheimer's disease (AD) exhibits age
dependent amyloid β (Aβ) plaque formation in their central nervous system due to high …

Glaucoma is a leading cause of permanent blindness worldwide and is characterized by
neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage …

Background Severe acute respiratory syndrome (SARS) has been initiating pandemics
since the beginning of the century. In December 2019, the world was hit again by a …

Glaucoma is characterized by the loss of retinal ganglion cells (RGC), and accordingly the
preservation of RGCs and their axons has recently attracted significant attention to improve …

Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …

The effects of insulin and type 1 insulin‐like growth factor (IGF–1) on metabolism, growth
and survival are mediated by their association with specific receptor tyrosine kinases, which …