The innate immune response to allotransplants: mechanisms and therapeutic potentials

J Ochando, F Ordikhani, P Boros… - Cellular & molecular …, 2019 - nature.com
Surgical trauma and ischemia reperfusion injury (IRI) are unavoidable aspects of any solid
organ transplant procedure. They trigger a multifactorial antigen-independent inflammatory …

Noble gas and neuroprotection: From bench to bedside

H Yin, Z Chen, H Zhao, H Huang, W Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
In recent years, inert gases such as helium, argon, and xenon have gained considerable
attention for their medical value. Noble gases present an intriguing scientific paradox …

Regulated cell death and inflammasome activation in gut injury following traumatic surgery in vitro and in vivo: implication for postoperative death due to multiorgan …

L Wu, H Zhao, M Zhang, Q Sun, E Chang, X Li… - Cell Death …, 2023 - nature.com
Postoperative multi-organ dysfunction (MOD) is associated with significant mortality and
morbidity. Necroptosis has been implicated in different types of solid organ injury; however …

[HTML][HTML] Snapshot: implications for mTOR in aging-related ischemia/reperfusion injury

D Liu, L Xu, X Zhang, C Shi, S Qiao, Z Ma… - Aging and …, 2019 - ncbi.nlm.nih.gov
Aging may aggravate the damage and dysfunction of different components of multiorgan
and thus increasing multiorgan ischemia/reperfusion (IR) injury. IR injury occurs in many …

Postoperative remote lung injury and its impact on surgical outcome

L Chen, H Zhao, A Alam, E Mi, S Eguchi, S Yao… - BMC …, 2019 - Springer
Postoperative remote lung injury is a complication following various surgeries and is
associated with short and long-term mortality and morbidity. The release of proinflammatory …

Vascular surgery-related organ injury and protective strategies: update and future prospects

B Yang, A Fung, C Pac-Soo, D Ma - BJA: British Journal of …, 2016 - academic.oup.com
Whilst there has been a reduction in the prevalence of peripheral vascular disease
worldwide, a significant proportion of the world's growing population is still affected by …

Xenon blunts NF-κB/NLRP3 inflammasome activation and improves acute onset of accelerated and severe lupus nephritis in mice

SR Yang, KF Hua, LJ Chu, YK Hwu, SM Yang, CY Wu… - Kidney International, 2020 - Elsevier
Xenon, an inert anesthetic gas, is increasingly recognized to possess desirable properties
including cytoprotective and anti-inflammatory effects. Here we evaluated the effects of …

Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review Action neuroprotectrice préclinique du xénon et …

M Maze - Can J Anesth/J Can Anesth, 2016 - search.proquest.com
Purpose The purpose of this report is to facilitate an understanding of the possible
application of xenon for neuroprotection in critical care settings. This narrative review …

Injury Site Specific Xenon Delivered by Platelet Membrane‐Mimicking Hybrid Microbubbles to Protect Against Acute Kidney Injury via Inhibition of Cellular …

J Yang, C Chen, X Miao, T Wang… - Advanced …, 2023 - Wiley Online Library
Inhalation of xenon gas improves acute kidney injury (AKI). However, xenon can only be
delivered through inhalation, which causes non‐specific distribution and low bioavailability …

[HTML][HTML] Osteopontin mediates necroptosis in lung injury after transplantation of ischaemic renal allografts in rats

H Zhao, Q Chen, H Huang, KC Suen, A Alam… - British journal of …, 2019 - Elsevier
Background Respiratory complications after surgery are associated with morbidity and
mortality. Acute lung injury can result from the systemic inflammatory response after acute …