Electrode materials for chronic electrical microstimulation

XS Zheng, C Tan, E Castagnola… - Advanced healthcare …, 2021 - Wiley Online Library
Electrical microstimulation has enabled partial restoration of vision, hearing, movement,
somatosensation, as well as improving organ functions by electrically modulating neural …

Bio-integrative design of the neural tissue-device interface

D Shi, V Dhawan, XT Cui - Current opinion in biotechnology, 2021 - Elsevier
Highlights•Bio-integrative strategies promote neural tissue-device integration.•Surface
modifications camouflage the surface and promote neuron attachment.•Drug delivery …

Reactive Amine Functionalized Microelectrode Arrays Provide Short-Term Benefit but Long-Term Detriment to In Vivo Recording Performance

BS Sturgill, AG Hernandez-Reynoso… - ACS Applied Bio …, 2024 - ACS Publications
Intracortical microelectrode arrays (MEAs) are used for recording neural signals. However,
indwelling devices result in chronic neuroinflammation, which leads to decreased recording …

[HTML][HTML] The effect of a Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) coating on the chronic recording performance of planar silicon intracortical microelectrode …

AG Hernandez-Reynoso, BS Sturgill, GF Hoeferlin… - Biomaterials, 2023 - Elsevier
Intracortical microelectrode arrays (MEAs) are used to record neural activity. However, their
implantation initiates a neuroinflammatory cascade, involving the accumulation of reactive …

Effects of neuronal cell adhesion molecule L1 and nanoparticle surface modification on microglia

N Kushwah, K Woeppel, V Dhawan, D Shi, XT Cui - Acta biomaterialia, 2022 - Elsevier
Microelectrode arrays for neural recording suffer from low yield and stability partly due to the
inflammatory host responses. A neuronal cell adhesion molecule L1 coating has been …

[HTML][HTML] Recent advances in in vivo neurochemical monitoring

C Tan, EM Robbins, B Wu, XT Cui - Micromachines, 2021 - mdpi.com
The brain is a complex network that accounts for only 5% of human mass but consumes
20% of our energy. Uncovering the mysteries of the brain's functions in motion, memory …

Carbohydrate based biomaterials for neural interface applications

V Dhawan, XT Cui - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Neuroprosthetic devices that record and modulate neural activities have demonstrated
immense potential for bypassing or restoring lost neurological functions due to neural …

Nanoparticle and biomolecule surface modification synergistically increases neural electrode recording yield and minimizes inflammatory host response

KM Woeppel, XT Cui - Advanced healthcare materials, 2021 - Wiley Online Library
Due to their ability to interface with neural tissues, neural electrodes are the key tool used for
neurophysiological studies, electrochemical detection, brain computer interfacing, and …

Zwitterionic polymer coating suppresses microglial encapsulation to neural implants in vitro and in vivo

Q Yang, B Wu, JR Eles, AL Vazquez… - Advanced …, 2020 - Wiley Online Library
For brain computer interfaces (BCI), the immune response to implanted electrodes is a major
biological cause of device failure. Bioactive coatings such as neural adhesion molecule L1 …

Surface area and local curvature: Why roughness improves the bioactivity of neural implants

R Ding, NC Miller, KM Woeppel, XT Cui, TDB Jacobs - Langmuir, 2022 - ACS Publications
While roughening the surface of neural implants has been shown to significantly improve
their performance, the mechanism for this improvement is not understood, preventing …