The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …

Cellular stress in the form of disrupted transcription, loss of organelle integrity, or damage to
nucleic acids can elicit inflammatory responses by activating signaling cascades canonically …

Germ line variants in the DDX41 gene have been linked to myelodysplastic syndromes
(MDS) and acute myeloid leukemia (AML) development. However, the risks associated with …

Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that primarily infects
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …

DExD/H-box helicases are crucial regulators of RNA metabolism and antiviral innate
immune responses; however, their role in bacteria-induced inflammation remains unclear …

DEAD-box helicases are multifunctional proteins participating in many aspects of cellular
RNA metabolism. DEAD-box helicase 41 (DDX41) in particular has pivotal roles in innate …

High-grade serous ovarian cancer (HGSC) is a challenging disease, especially for patients
with immunologically “cold” tumors devoid of tumor-infiltrating lymphocytes (TILs). We found …

In myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic
syndromes (MDS), patient selection and therapeutic strategies are increasingly based on …