Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal
(HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors …

Background The human hypothalamic–pituitary‐gonadal (HPG) axis is the regulatory center
for pubertal development. This axis involves six G‐protein coupled receptors (GPCRs) …

Sexual maturation is a complex physiological process that involves multiple variables, such
as genetic and environmental factors. Among females, age at menarche (AM) is a critical …

Pubertal onset is a complex process, which is influenced by genetic and environmental
factors, such as obesity and endocrine-disrupting chemicals. In addition, the timing of normal …

The rise in precocious puberty cases can be attributed to a combination of genetic and
environmental factors. Genetic factors play a significant role, with studies identifying genetic …