Dry eye disease associated with meibomian gland dysfunction: focus on tear film characteristics and the therapeutic landscape

JD Sheppard, KK Nichols - Ophthalmology and Therapy, 2023 - Springer
Meibomian gland dysfunction (MGD) is highly prevalent and is the leading cause of
evaporative dry eye disease (DED). MGD is characterized by a reduction in meibum …

Treatment of non-infectious corneal injury: review of diagnostic agents, therapeutic medications, and future targets

DH Dang, KM Riaz, D Karamichos - Drugs, 2022 - Springer
Corneal injuries can occur secondary to traumatic, chemical, inflammatory, metabolic,
autoimmune, and iatrogenic causes. Ocular infection may frequently occur concurrent to …

Ocular instillation of conditioned medium from mesenchymal stem cells is effective for dry eye syndrome by improving corneal barrier function

T Imaizumi, R Hayashi, Y Kudo, X Li, K Yamaguchi… - Scientific Reports, 2023 - nature.com
Dry eye syndrome (DES) is a chronic ocular disease that induces epithelial damage to the
cornea by decreasing tear production and quality. Adequate treatment options have not …

Understanding chronic ocular surface pain: an unmet need for targeted drug therapy

A Galor, P Hamrah, S Haque, N Attal, M Labetoulle - The ocular surface, 2022 - Elsevier
Chronic ocular surface pain (COSP) may be defined as a feeling of pain, perceived as
originating from the ocular surface, that persists for> 3 months. COSP is a complex …

Impact of glaucoma medications on the ocular surface and how ocular surface disease can influence glaucoma treatment

M Kolko, G Gazzard, C Baudouin, S Beier… - The ocular …, 2023 - Elsevier
Glaucoma is a common disease with an increasing prevalence [1]. Ocular surface disease
(OSD) is also common, and its prevalence is increasing [2, 3], due in part to the adverse …

Aqueous prostaglandin eye drop formulations

P Jansook, T Loftsson - Pharmaceutics, 2022 - mdpi.com
Glaucoma is one of the leading causes of irreversible blindness worldwide. It is
characterized by progressive optic neuropathy in association with damage to the optic nerve …

Pickering emulsions stabilised with oligoglycine-functionalised nanodiamond as a model system for ocular drug delivery applications

Z Huang, RV Moiseev, SS Melides, W Bae, I Jurewicz… - Soft matter, 2023 - pubs.rsc.org
Oil-in-water emulsions, stabilised with conventional surfactants, are commonly used in eye
drops for ocular drug delivery. However, the presence of surfactants can sometimes irritate …

Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent

A Ballesteros-Sanchez, C De-Hita-Cantalejo… - The Ocular Surface, 2023 - Elsevier
Abstract Perfluorohexyloctane (F6H8), a physically and chemically inert synthetic
compound, has recently emerged as a promising candidate for the treatment of DED due to …

Highlighting the microbial contamination of the dropper tip and cap of in-use eye drops, the associated contributory factors, and the risk of infection: a past-30-years …

K Iskandar, L Marchin, L Kodjikian, M Rocher… - Pharmaceutics, 2022 - mdpi.com
The sterility of eye drop content is a primary concern from manufacturing until opening, as
well as during handling by end users, while microbial contamination of the dropper tip and …

Polyaphron formulations stabilised with different water-soluble polymers for ocular drug delivery

RV Moiseev, F Steele, VV Khutoryanskiy - Pharmaceutics, 2022 - mdpi.com
As drug delivery to the eye has evolved over the last decades, researchers have explored
more effective treatments for ocular diseases. Despite this, delivering drugs to the cornea …