A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

The Dishevelled protein regulates many developmental processes in animals ranging from
Hydra to humans. Here, we discuss the various known signaling activities of this enigmatic …

Mesenchymal stem cell-derived exosomes (MSC-Ex) play important roles in tissue injury
repair, however, the roles of MSC-Ex in skin damage repair and its mechanisms are largely …

Cell to cell communication is vital throughout the development of multicellular organisms
and during adult homeostasis. One way in which communication is achieved is through the …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …

The wingless/int1 (WNT)/F rizzled (FZD) signalling pathway controls numerous cellular
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …

Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …

The receptor class Frizzled, which has recently been categorized as a separate group of G
protein-coupled receptors by the International Union of Basic and Clinical Pharmacology …

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the
maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present …

The seven-transmembrane-spanning receptors of the FZD 1–10 class are bound and
activated by the WNT family of lipoglycoproteins, thereby inducing a complex network of …