Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

Several attempts have been made to treat Alzheimer's disease (AD) using anti-amyloid
strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone …

Psychotic symptoms, delusions and hallucinations, occur in approximately 50% of
individuals with Alzheimer's disease (AD)(AD with psychosis [AD+ P]). Pharmacotherapies …

Variant syndromes of Alzheimer disease (AD), led by deficits that extend beyond memory
dysfunction, are of considerable clinical and neurobiological importance. Such syndromes …

Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …

Abstract Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost
90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to …

After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …

The molecular mechanism of neuronal loss and synaptic damage in Alzheimer's disease
(AD), Parkinson's disease dementia (PDD), frontotemporal dementia (FTD) and Lewy body …

The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While
cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic …