A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

E Sweetman, T Kleffmann, C Edgar… - Journal of translational …, 2020 - Springer
Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a
serious and complex physical illness that affects all body systems with a multiplicity of …

Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson's disease

D Flinkman, Y Hong, J Gnjatovic, P Deshpande… - npj Parkinson's …, 2023 - nature.com
Deficits in protein synthesis are associated with Parkinson's disease (PD). However, it is not
known which proteins are affected or if there are synthesis differences between patients with …

Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease

G Novak, D Kyriakis, K Grzyb, M Bernini… - Communications …, 2022 - nature.com
Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder,
characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The underlying …

The potential mechanism of mitochondrial homeostasis in postoperative neurocognitive disorders: an in-depth review

F Ye, C Wei, A Wu - Annals of Medicine, 2024 - Taylor & Francis
Postoperative neurocognitive disorders (PND) are the most common neurological disorders
following surgery and anaesthesia before and within 12 months after surgery, with a high …

Navigating the Gene Co-Expression Network and Drug Repurposing Opportunities for Brain Disorders Associated with Neurocognitive Impairment

MTA Manuel, LL Tayo - Brain Sciences, 2023 - mdpi.com
Neurocognitive impairment refers to a spectrum of disorders characterized by a decline in
cognitive functions such as memory, attention, and problem-solving, which are often linked …

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein

HC Wu, QL Hu, SJ Zhang, YM Wang… - Neural regeneration …, 2018 - journals.lww.com
Genistein, a potent antioxidant compound, protects dopaminergic neurons in a mouse
model of Parkinson's disease. However, the mechanism underlying this action remains …

Proteomic changes driven by urban pollution suggest particulate matter as a deregulator of energy metabolism, mitochondrial activity, and oxidative pathways in the …

JE Araújo, S Jorge, HM Santos, A Chiechi… - Science of the total …, 2019 - Elsevier
The adverse effects of air pollution have been long studied in the lung and respiratory
systems, but the molecular changes that this causes at the central nervous system level …

Research into super-resolution in medical imaging from 2000 to 2023: bibliometric analysis and visualization

J He, H Ma, M Guo, J Wang, Z Wang… - Quantitative Imaging in …, 2024 - pmc.ncbi.nlm.nih.gov
Background Super-resolution (SR) refers to the use of hardware or software methods to
enhance the resolution of low-resolution (LR) images and produce high-resolution (HR) …

Targeting mitochondrial defects to increase longevity in animal models of neurodegenerative diseases

E Casajus Pelegay, F Puzzo, A Yilmazer… - Reviews on Biomarker …, 2019 - Springer
Bioenergetic homeostasis is a vital process maintaining cellular health and has primary
importance in neuronal cells due to their high energy demand markedly at synapses …

Multiple Criteria Optimization (MCO): A gene selection deterministic tool in RStudio

I Narváez-Bandera, D Suárez-Gómez, CE Isaza… - PloS one, 2022 - journals.plos.org
Identifying genes with the largest expression changes (gene selection) to characterize a
given condition is a popular first step to drive exploration into molecular mechanisms and is …