Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain
Brain metastasis, a serious complication of cancer, hinges on the initial survival,
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …
TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas
Background Myeloid cells comprise up to 50% of the total tumor mass in glioblastoma (GBM)
and have been implicated in promoting tumor progression and immunosuppression …
and have been implicated in promoting tumor progression and immunosuppression …
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived …
YA Yabo, PM Moreno-Sanchez, Y Pires-Afonso… - Genome Medicine, 2024 - Springer
Background A major contributing factor to glioblastoma (GBM) development and
progression is its ability to evade the immune system by creating an immune-suppressive …
progression is its ability to evade the immune system by creating an immune-suppressive …
GAS-Luc2 Reporter Cell Lines for Immune Checkpoint Drug Screening in Solid Tumors
H Chang, JG Foulke, L Chen, F Tian, Z Gu - Cancers, 2024 - mdpi.com
Simple Summary Despite the recent studies emphasizing the importance of the interferon
gamma receptor (IFNγR) pathway in T cell-mediated cytotoxicity against solid tumors, full …
gamma receptor (IFNγR) pathway in T cell-mediated cytotoxicity against solid tumors, full …
GAS-Luc2 Reporter Cell Lines for Immune Checkpoint Drug Screening in Solid Tumors
Z Gu, H Chang, K Tyo, J Foulke, L Chen, F Tian - 2023 - researchsquare.com
Recent studies highlight the integral role of the interferon gamma receptor pathway in T cell-
mediated cytotoxicity against solid but not liquid tumors. IFNγ not only directly facilitates …
mediated cytotoxicity against solid but not liquid tumors. IFNγ not only directly facilitates …