Obesity is an excessive adipose tissue accumulation that may have detrimental effects on
health. Particularly, childhood obesity has become one of the main public health problems in …

Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

Purpose Inulin is a type of fermentable dietary fiber, which is non-digestible, and can
improve metabolic function by modulating intestinal microbiota. This study aimed to evaluate …

Background The multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by
ABCB1) and breast cancer resistance protein (BCRP/ABCG2) contribute to the blood–brain …

Drug-induced liver injury (DILI) is one of the most frequent sources of liver failure and the
leading cause of liver transplant. Common non-prescription medications such as non …

The development of multidrug resistance in cancer chemotherapy is a major obstacle to the
effective treatment of human malignant tumors. Several epidemiological studies have …

ABSTRACT Introduction: Janus kinase inhibitors (JAKinibs) constitute an emerging and
promising pharmacological class of anti-inflammatory or anti-cancer drugs, used notably for …

Janus kinases (Jaks) are a family of nonreceptor tyrosine kinase that include four different
members, viz., Jak1, Jak2, Jak3, and Tyk2. Jaks play critical roles in immune cells functions; …

Colorectal cancer (CRC) is an aggressive malignancy with very limited therapeutic
approaches. Drug resistance develops as a frequent characteristic in many patients with …

Drug efficacy is dependent on the pharmacokinetics and pharmacodynamics of therapeutic
agents. Tight junctions, detoxification enzymes, and drug transporters, due to their …