Using deep learning to study emotional behavior in rodent models

JY Kuo, AJ Denman, NJ Beacher… - Frontiers in Behavioral …, 2022 - frontiersin.org
Quantifying emotional aspects of animal behavior (eg, anxiety, social interactions, reward,
and stress responses) is a major focus of neuroscience research. Because manual scoring …

The role of opioid transmission in music‐induced pleasure

E Mas‐Herrero, L Ferreri, G Cardona… - Annals of the New …, 2023 - Wiley Online Library
Studies conducted in rodents indicate a crucial role of the opioid circuit in mediating
objective hedonic reactions to primary rewards. However, it remains unclear whether opioid …

Beauty and uncertainty as transformative factors: a free energy principle account of aesthetic diagnosis and intervention in Gestalt psychotherapy

P Sarasso, G Francesetti, J Roubal… - Frontiers in Human …, 2022 - frontiersin.org
Drawing from field theory, Gestalt therapy conceives psychological suffering and
psychotherapy as two intentional field phenomena, where unprocessed and chaotic …

The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research

X Li, G Kass, CE Wiers, Z Shi - Current Addiction Reports, 2024 - Springer
Abstract Purpose of Review The brain's salience network (SN), primarily comprising the
anterior insula and anterior cingulate cortex, plays a key role in detecting salient stimuli and …

Drug repurposing candidates to treat core symptoms in autism spectrum disorder

E Koch, D Demontis - Frontiers in Pharmacology, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is characterized by high heritability and clinical
heterogeneity. The main core symptoms are social communication deficits. There are no …

Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma

DM Gescher, D Schanze, P Vavra, P Wolff… - Molecular …, 2024 - nature.com
According to a growing body of neurobiological evidence, the core symptoms of borderline
personality disorder (BPD) may be linked to an opioidergic imbalance between the hedonic …

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

L Sun, L Lukkarinen, V Putkinen… - … of the Royal …, 2022 - royalsocietypublishing.org
Laughter is a contagious prosocial signal that conveys bonding motivation; adult crying
conversely communicates desire for social proximity by signalling distress. Endogenous mu …

A history of childhood maltreatment has substance-and sex-specific effects on craving during treatment for substance use disorders

S Gerhardt, K Eidenmueller, S Hoffmann… - Frontiers in …, 2022 - frontiersin.org
Rationale Childhood maltreatment (CM) leads to detrimental mental health outcomes, such
as substance use disorders (SUD). This study examined prevalence and severity of all five …

Intracerebroventricular injection of sclerostin reduced social hierarchy and impaired neuronal dendritic complexity in mice

W Li, Y Zhang, Y Su, Y Hao, X Wang, X Yin, M Gong… - Neuroscience …, 2022 - Elsevier
An increasing number of studies have demonstrated extensive functional links between
bone and the brain. As a novel endocrine organ, bone has received increasing attention for …

Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.

DN King'uyu, EL Edgar, C Figueroa… - Behavioral …, 2023 - psycnet.apa.org
Drug exposure during adolescence, when the “reward” circuitry of the brain is developing,
can permanently impact reward-related behavior into adulthood. Epidemiological studies …