Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

The proteasome is a large multi-subunit protease responsible for the degradation and
removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays …

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity …

Protein translation is an essential cellular process playing key roles in growth and
development. Protein translation declines over the course of age in multiple animal species …

Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and
physical frailty. While predictors of each element are well-researched, mechanisms of their …

The proteasome is a multi-subunit proteolytic complex that functions to degrade normal
proteins for physiological regulation and to eliminate abnormal proteins for cellular …

Protein folding is a substantively error prone process, especially when it occurs in the
endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory …

Proteasome activation has been shown to promote cellular and organismal healthspan and
to protect against aggregation-related conditions, such as Alzheimer's disease (AD). Various …

Autophagy is a major cellular recycling process that delivers cellular material and entire
organelles to lysosomes for degradation, in a selective or non-selective manner. This …

The failure of the proper protein turnover in the nervous system is mainly linked to a variety
of neurodegenerative disorders. Therefore, a better understanding of key protein …