Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell
killing by CD8+ T cells recognizing cognate antigens presented in the context of target cell …

Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Chimeric antigen receptor (CAR) engineering of T cells has revolutionized the field of
cellular therapy for the treatment of cancer. Despite this success, autologous CAR-T cells …

Immuno‐oncology is revolutionizing the treatment of cancers, by inducing the recognition
and elimination of tumor cells by the immune system. Recent advances have focused on …

The association between cancer and autoimmune disease is unexplained, exemplified by T
cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic …

The approval of CD19 chimeric antigen receptor (CAR)-engineered T (CAR-T) cell products
in B-cell malignancies represents a breakthrough in CAR-T cell immunotherapy. However …

CAR-T (chimeric antigen receptor T) cells have emerged as a milestone in the treatment of
patients with refractory B-cell neoplasms. However, despite having unprecedented efficacy …

Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …