Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Understanding the etiology and pathogenesis schizophrenia and depression is a major
challenge facing psychiatry. One hypothesis is that these disorders are secondary to a …

BACKGROUND: Because researchers have reported that antidepressants increase the
expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus, we …

Chronic pain during childhood and adolescence can lead to persistent pain problems and
mental health disorders into adulthood. Posttraumatic stress disorders and depressive and …

Aims/Objectives/Background: A significant number of people who experience chronic pain
also complain of depression and sleep problems. The comorbidities and bidirectional …

Brain-derived neurotrophic factor (BDNF), the most abundant neurotrophin in the brain, has
a known association with the pathophysiology of anxiety and depression. However, the role …

The original definition of atypical antipsychotic drugs (APD) was drugs that are effective
against positive symptoms in schizophrenia with no or little extrapyramidal symptoms (EPS) …

The growth factor brain-derived neurotrophic factor (BDNF), and its receptor tropomyosin-
related kinase receptor type B (TrkB) play an active role in numerous areas of the adult …

The Flinders Sensitive Line (FSL) rats were originally selectively bred for increased
responses to an anticholinesterase agent. The FSL rat partially resembles depressed …

A number of lines of converging evidence suggest that brain-derived neurotrophic factor
(BDNF) may play a role in the onset and treatment of bipolar disorder. We review pertinent …