[HTML][HTML] Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action

GL Hammond - The Journal of endocrinology, 2016 - ncbi.nlm.nih.gov
Biologically active steroids are transported in the blood by albumin, sex hormone-binding
globulin (SHBG), and corticosteroid-binding globulin (CBG). These plasma proteins also …

Estrogen: a master regulator of bioenergetic systems in the brain and body

JR Rettberg, J Yao, RD Brinton - Frontiers in neuroendocrinology, 2014 - Elsevier
Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …

Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels

RS Swerdloff, RE Dudley, ST Page, C Wang… - Endocrine …, 2017 - academic.oup.com
Benefits associated with lowered serum DHT levels after 5 α-reductase inhibitor (5AR-I)
therapy in men have contributed to a misconception that circulating DHT levels are an …

[HTML][HTML] The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis

H Chaudhary, J Patel, NK Jain, R Joshi - Journal of ovarian research, 2021 - Springer
Polycystic ovary syndrome (PCOS) is the most common endocrinopathies affecting the early
reproductive age in women, whose pathophysiology perplexes many researchers till today …

[HTML][HTML] Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: a longitudinal study based on a United Kingdom …

B Kumarendran, MW O'Reilly, KN Manolopoulos… - PLoS …, 2018 - journals.plos.org
Background Androgen excess is a defining feature of polycystic ovary syndrome (PCOS),
which affects 10% of women and represents a lifelong metabolic disorder, with increased …

Sex hormone binding globulin and insulin resistance

IR Wallace, MC McKinley, PM Bell… - Clinical …, 2013 - Wiley Online Library
Sex hormone binding globulin (SHBG) is a glycoprotein composed of two 373‐amino‐acid
subunits. The SHBG gene and a promotor region have been identified. The SHBG receptor …

Sex hormone binding globulin-an important biomarker for predicting PCOS risk: A systematic review and meta-analysis

R Deswal, A Yadav, AS Dang - Systems biology in reproductive …, 2018 - Taylor & Francis
Sex hormone-binding globulin (SHBG) is a glycoprotein which regulates bioavailability of
sex steroid hormones. Interest in SHBG has escalated in recent years because of its inverse …

[HTML][HTML] Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

MR Laurent, GL Hammond, M Blokland, F Jardí… - Scientific reports, 2016 - nature.com
Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and
estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex …

Androgen misuse and abuse

DJ Handelsman - Endocrine Reviews, 2021 - academic.oup.com
Androgens are potent drugs requiring prescription for valid medical indications but are
misused for invalid, unproven, or off-label reasons as well as being abused without …

Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus–pituitary–gonadal axis of CD-1 mice

W Xi, CKF Lee, WSB Yeung, JP Giesy, MH Wong… - Reproductive …, 2011 - Elsevier
Bisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the
environment. Adverse effects of BPA on animal reproductive health have been reported …