G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …

Class B1 G protein-coupled receptors (GPCRs) play important roles in human physiology
and disease pathology. Using cryo-electron microscopy (cryo-EM) and X-ray …

Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP),
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several …

Glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR), two members of
class B1 G protein–coupled receptors, play important roles in glucose homeostasis and …

G protein-coupled receptors (GPCRs) generally accommodate specific ligands in the
orthosteric-binding pockets. Ligand binding triggers a receptor allosteric conformational …

G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins,
regulate a wide array of physiological processes in response to extracellular signals …

G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one of
the prime targets for marketed drugs. While traditional drug discovery programs have …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Abstract Glucagon-like peptide-1 receptor (GLP-1R) is a well-studied incretin hormone
receptor and target of several therapeutic drugs for type 2 diabetes (T2D), obesity and, more …

G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …