POSREG: proteomic signature discovered by simultaneously optimizing its reproducibility and generalizability

F Li, Y Zhou, Y Zhang, J Yin, Y Qiu… - Briefings in …, 2022 - academic.oup.com
Mass spectrometry-based proteomic technique has become indispensable in current
exploration of complex and dynamic biological processes. Instrument development has …

[HTML][HTML] On the road to accurate protein biomarkers in prostate cancer diagnosis and prognosis: current status and future advances

Y Yan, SY Yeon, C Qian, S You, W Yang - International Journal of …, 2021 - mdpi.com
Prostate cancer (PC) is a leading cause of morbidity and mortality among men worldwide.
Molecular biomarkers work in conjunction with existing clinicopathologic tools to help …

Pharmacometabonomics: data processing and statistical analysis

J Fu, Y Zhang, J Liu, X Lian, J Tang… - Briefings in …, 2021 - academic.oup.com
Individual variations in drug efficacy, side effects and adverse drug reactions are still
challenging that cannot be ignored in drug research and development. The aim of …

Mechanism of zinc ejection by disulfiram in nonstructural protein 5A

AU Rehman, G Zhen, B Zhong, D Ni, J Li… - Physical Chemistry …, 2021 - pubs.rsc.org
Hepatitis C virus (HCV) is a notorious member of the Flaviviridae family of enveloped,
positive-strand RNA viruses. Non-structural protein 5A (NS5A) plays a key role in HCV …

[HTML][HTML] Identification of the diagnostic genes and immune cell infiltration characteristics of gastric cancer using bioinformatics analysis and machine learning

R Xie, L Liu, X Lu, C He, G Li - Frontiers in Genetics, 2023 - frontiersin.org
Background: Finding reliable diagnostic markers for gastric cancer (GC) is important. This
work uses machine learning (ML) to identify GC diagnostic genes and investigate their …

A novel hypoxia-driven gene signature that can predict the prognosis of hepatocellular carcinoma

Z Zeng, S Lei, J Wang, Y Yang, J Lan, Q Tian… - …, 2022 - Taylor & Francis
Hypoxia environment exists in already started hepatocellular carcinoma (HCC) and
promotes its progression by driving changes in the gene expression profiles of cells …

[HTML][HTML] Analysis of potential genetic biomarkers using machine learning methods and immune infiltration regulatory mechanisms underlying atrial fibrillation

LD Wu, F Li, JY Chen, J Zhang, LL Qian… - BMC Medical …, 2022 - Springer
Objective We aimed to screen out biomarkers for atrial fibrillation (AF) based on machine
learning methods and evaluate the degree of immune infiltration in AF patients in detail …

Combining multi-dimensional molecular fingerprints to predict the hERG cardiotoxicity of compounds

W Ding, Y Nan, J Wu, C Han, X Xin, S Li, H Liu… - Computers in Biology …, 2022 - Elsevier
Recently, drug toxicity has become a critical problem with heavy medical and economic
burdens. Acquired long QT syndrome (acLQTS) is an acquired cardiac ion channel disease …

[HTML][HTML] Identifying potential biomarkers of idiopathic pulmonary fibrosis through machine learning analysis

Z Wu, H Chen, S Ke, L Mo, M Qiu, G Zhu, W Zhu… - Scientific Reports, 2023 - nature.com
Idiopathic pulmonary fibrosis (IPF) is the most common and serious type of idiopathic
interstitial pneumonia, characterized by chronic, progressive, and low survival rates, while …

[HTML][HTML] CXCL5 expression in tumor tissues is associated with poor prognosis in patients with pancreatic cancer

B Wu, J Wang, X Wang, M Zhu, F Chen… - Oncology …, 2020 - spandidos-publications.com
Immunotherapy based on the tumor microenvironment is a feasible method for treating
cancer; therefore, it is necessary to investigate the immune microenvironment of pancreatic …