The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

Thyroid hormones (THs) are secreted by the thyroid gland. They control lipid, carbohydrate,
and protein metabolism, heart rate, neural development, as well as cardiovascular, renal …

Covering: 1934 to early 2002. The biochemistry of selenium-containing natural products,
including selenoproteins, is reviewed up to May 2002. Particular emphasis is placed on the …

We investigated the requirements for selenocysteine insertion at single or multiple UGA
codons in eukaryotic selenoproteins. Two functional SECIS elements were identified in the …

As is typical of other hormone systems, the actions of the thyroid hormones (TH) differ from
tissue to tissue depending upon a number of variables. In addition to varying expression …

Selenoprotein biosynthesis is mediated by tRNASec, which inserts selenocysteine at UGA
codons in a complex, context-specific manner. This opal suppressor serves in the …