Hypertension (HTN) is present in more than 50% of patients with diabetes mellitus (DM) and
contributes significantly to both microvascular and macrovascular disease in DM (Fig. 1). 1 …

Alzheimer's disease (AD) is the most common form of dementia affecting elderly people. AD
is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques …

摘要背景白藜芦醇是一种植物抗毒素, 对人体健康有益, 本研究的目的是调查白藜芦醇对胰岛素
信号和炎症中内皮功能障碍的影响. 方法: 使用棕榈酸酯激活内皮细胞, 以产生以胰岛素介导的一 …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Context: Hesperidin, a citrus flavonoid, and its metabolite hesperetin may have vascular
actions relevant to their health benefits. Molecular and physiological mechanisms of …

Micro-and macrovascular complications are major causes of disability and death in patients
with diabetes mellitus. Functional impairment of endothelial activity precedes the …

The term double diabetes (DD) has been used to refer to individuals with type 1 diabetes
(T1D) who are overweight, have a family history of type 2 diabetes and/or clinical features of …

Previously, we have used mathematical modeling to gain mechanistic insights into insulin-
stimulated glucose uptake. Phosphatidylinositol 3-kinase (PI3K)-dependent insulin signaling …

Objective Atherosclerosis is a complex process characterized by an increase in vascular
wall thickness owing to the accumulation of cells and extracellular matrix between the …

Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the
right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be …