Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Copper-64: a real theranostic agent

B Gutfilen, SAL Souza, G Valentini - Drug design, development and …, 2018 - Taylor & Francis
Ongoing studies of physiological and pathological processes have led to a corresponding
need for new radiopharmaceuticals, especially when studies are limited by the absence of a …

[图书][B] Handbook on the physics and chemistry of rare earths: including actinides

JCG Bunzli, VK Pecharsky - 2016 - books.google.com
Handbook on the Physics and Chemistry of Rare Earths: Including Actinides is a continuous
series of books covering all aspects of rare earth science, including chemistry, life sciences …

Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals

Z Cai, CJ Anderson - Journal of labelled compounds and …, 2014 - Wiley Online Library
The development of chelating agents for copper radionuclides in positron emission
tomography radiopharmaceuticals has been a highly active and important area of study in …

NOTA complexes with copper (II) and divalent metal ions: kinetic and thermodynamic studies

V Kubicek, Z Bohmova, R Sevcikova, J Vanek… - Inorganic …, 2018 - ACS Publications
H3nota derivatives are among the most studied macrocyclic ligands and are widely used for
metal ion binding in biology and medicine. Despite more than 40 years of chemical research …

[HTML][HTML] Current and future theranostic applications of the lipid-calcium-phosphate nanoparticle platform

AB Satterlee, L Huang - Theranostics, 2016 - ncbi.nlm.nih.gov
Over the last four years, the Lipid-Calcium-Phosphate (LCP) nanoparticle platform has
shown success in a wide range of treatment strategies, recently including theranostics. The …

[HTML][HTML] On the dissociation pathways of copper complexes relevant as PET imaging agents

R Uzal-Varela, V Patinec, R Tripier, L Valencia… - Journal of Inorganic …, 2022 - Elsevier
Several bifunctional chelators have been synthesized in the last years for the development
of new 64 Cu-based PET agents for in vivo imaging. When designing a metal-based PET …

Measurement of the rate of copper (II) exchange for 64Cu complexes of bifunctional chelators

V Maheshwari, JLJ Dearling, ST Treves… - Inorganica Chimica …, 2012 - Elsevier
Measurement of the rate of loss of 64Cu from the chelators used in the preparation of 64Cu-
labeled proteins is critical to the development of effective 64Cu-labeled …

Is less more? Influence of the coordination geometry of Copper (II) picolinate chelate complexes on metabolic stability

BA Vaughn, AM Brown, SH Ahn, JR Robinson… - Inorganic …, 2020 - ACS Publications
A growing number of copper (II) complexes have been identified as suitable candidates for
biomedical applications. Here, we show that the biocompatibility and stability of copper (II) …

Cyclam-Based Chelators Bearing Phosphonated Pyridine Pendants for 64Cu-PET Imaging: Synthesis, Physicochemical Studies, Radiolabeling, and Bioimaging

RC Knighton, T Troadec, V Mazan, P Le Saëc… - Inorganic …, 2021 - ACS Publications
Herein we present the preparation of two novel cyclam-based macrocycles (te1pyp and cb-
te1pyp), bearing phosphonate-appended pyridine side arms for the coordination of copper …