Colorectal cancer (CRC) has predominantly been considered a genetic disease,
characterized by sequential accumulation of genetic alterations. Growing evidence indicates …

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome
characterised by a predisposition to early onset colorectal, endometrial and other cancers …

A three-dimensional chromatin state underpins the structural and functional basis of the
genome by bringing regulatory elements and genes into close spatial proximity to ensure …

Most colorectal cancers (CRCs) containing activated BRAF (BRAF [V600E]) have a CpG
island methylator phenotype (CIMP) characterized by aberrant hypermethylation of many …

To investigate the three-dimensional (3D) genome architecture across normal B cell
differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia …

Background: Few risk factors for childhood cancer are well-established. We investigated
whether advancing parental age increases childhood cancer risk. Methods: We assessed …

Silencing of individual genes can occur by genetic and epigenetic processes during
carcinogenesis, but the underlying mechanisms remain unclear. By creating an integrated …

Introduction Colorectal cancer (CRC) diagnosed before age 30 years is a fatal disease
whose biology remains poorly understood. To understand its pathogenesis, we compared …

The genetic and epigenetic alterations that underlie cancer pathogenesis are rapidly being
identified. This provides novel insights in tumor biology as well as in potential cancer …

Abstract Changes in DNA methylation patterns are a common characteristic of cancer cells.
Recent studies suggest that DNA methylation affects not only discrete genes, but it can also …