Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …

Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac) …

Background—Oxidative stress may contribute to heart failure (HF) progression. Inhibiting
xanthine oxidase in hyperuricemic HF patients may improve outcomes. Methods and …

Introduction: Urate-lowering therapy (ULT) is the cornerstone of gout management, which is
a widespread chronic illness characterized by hyperuricemia, arthropathy, tophus …

Objective Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …

Allopurinol is the most commonly prescribed urate-lowering therapy for the management of
gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to …

Many forms of cancer present with a complex metabolic profile characterised by loss of lean
body mass known as cancer cachexia. The physical impact of cachexia contributes to …

Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …

This article aims to critically review the evidence on the available therapeutic strategies for
the treatment of hyperuricemia. For this reason, several papers were reviewed. Xanthine …