Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease

AM Macedo, CR Machado, RP Oliveira… - Memorias do Instituto …, 2004 - SciELO Brasil
Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical
course, ranging from symptomless infection to severe chronic disease with cardiovascular or …

Direct molecular profiling of minicircle signatures and lineages of Trypanosoma cruzi bloodstream populations causing congenital Chagas disease

JM Burgos, J Altcheh, M Bisio, T Duffy… - International journal for …, 2007 - Elsevier
Congenital transmission of Trypanosoma cruzi may occur in some or all the gestations from
a T. cruzi-infected mother. Variable rates of congenital transmission have been reported in …

Triatominae–Trypanosoma cruzi/T. rangeli: Vector–parasite interactions

GA Vallejo, F Guhl, GA Schaub - Acta tropica, 2009 - Elsevier
Of the currently known 140 species in the family Reduviidae, subfamily Triatominae, those
which are most important as vectors of the aetiologic agent of Chagas disease …

[HTML][HTML] Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease

CA Buscaglia, JM Di Noia - Microbes and infection, 2003 - Elsevier
Chagas' disease is caused by the protozoan Trypanosoma cruzi and it has a variable
clinical outcome. The basis for this variability relies in part on the complexity of the parasite …

Should Trypanosoma cruzi be called" cruzi" complex? A review of the parasite diversity and the potential of selecting population after in vitro culturing and mice …

R Devera, O Fernandes, JR Coura - Memórias do Instituto Oswaldo …, 2003 - SciELO Brasil
Morpho-biological diversity of Trypanosoma cruzi has been known since Chagas' first works
in 1909. Several further studies confirmed the morphological differences among the parasite …

Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease

M Moreno, DA D'ávila, MN Silva, L Galvão… - Memorias do Instituto …, 2010 - SciELO Brasil
Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has
been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi …

Trypanosoma cruzi IV Causing Outbreaks of Acute Chagas Disease and Infections by Different Haplotypes in the Western Brazilian Amazonia

WM Monteiro, LKC Magalhães, ARN de Sá, ML Gomes… - 2012 - journals.plos.org
Background Chagas disease is an emergent tropical disease in the Brazilian Amazon
Region, with an increasing number of cases in recent decades. In this region, the sylvatic …

Multilocus Microsatellite Typing as a New Tool for Discrimination of Leishmania infantum MON-1 Strains

S Ochsenreither, K Kuhls, M Schaar… - Journal of clinical …, 2006 - Am Soc Microbiol
The Leishmania donovani complex, which consists of L. donovani, L. infantum-L. chagasi,
and L. archibaldi, is responsible for visceral manifestations of leishmaniasis. Multilocus …

Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages

A Izeta-Alberdi, CN Ibarra-Cerdeña, DA Moo-Llanes… - Parasites & …, 2016 - Springer
Background The evolutionary history and ecological associations of Trypanosoma cruzi, the
need to identify genetic markers that can distinguish parasite subpopulations, and …