BAC to the future! or oligonucleotides: a perspective for micro array comparative genomic hybridization (array CGH)
B Ylstra, P van den IJssel, B Carvalho… - Nucleic acids …, 2006 - academic.oup.com
The array CGH technique (Array Comparative Genome Hybridization) has been developed
to detect chromosomal copy number changes on a genome-wide and/or high-resolution …
to detect chromosomal copy number changes on a genome-wide and/or high-resolution …
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
Background MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants
and animals, often act post-transcriptionally to inhibit gene expression. Results Here we …
and animals, often act post-transcriptionally to inhibit gene expression. Results Here we …
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
Background Medulloblastoma is the most common malignant brain tumor in children.
Despite recent improvements in cure rates, prediction of disease outcome remains a major …
Despite recent improvements in cure rates, prediction of disease outcome remains a major …
QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data
Array-based technologies have been used to detect chromosomal copy number changes
(aneuploidies) in the human genome. Recent studies identified numerous copy number …
(aneuploidies) in the human genome. Recent studies identified numerous copy number …
Recruitment to the nuclear periphery can alter expression of genes in human cells
LE Finlan, D Sproul, I Thomson, S Boyle, E Kerr… - PLoS …, 2008 - journals.plos.org
The spatial organisation of the genome in the nucleus has a role in the regulation of gene
expression. In vertebrates, chromosomal regions with low gene-density are located close to …
expression. In vertebrates, chromosomal regions with low gene-density are located close to …
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
Background The characterization of copy number alteration patterns in breast cancer
requires high-resolution genome-wide profiling of a large panel of tumor specimens. To …
requires high-resolution genome-wide profiling of a large panel of tumor specimens. To …
Array-CGH and breast cancer
EH van Beers, PM Nederlof - Breast Cancer Research, 2006 - Springer
The introduction of comparative genomic hybridization (CGH) in 1992 opened new avenues
in genomic investigation; in particular, it advanced analysis of solid tumours, including …
in genomic investigation; in particular, it advanced analysis of solid tumours, including …
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
HG Russnes, HKM Vollan, OC Lingjærde… - Science translational …, 2010 - science.org
Distinct molecular subtypes of breast carcinomas have been identified, but translation into
clinical use has been limited. We have developed two platform-independent algorithms to …
clinical use has been limited. We have developed two platform-independent algorithms to …
[HTML][HTML] Resolving the resolution of array CGH
Many recent technologies have been designed to supplant conventional metaphase CGH
technology with the goal of refining the description of segmental copy number status …
technology with the goal of refining the description of segmental copy number status …
Relevance of PTEN loss in brain metastasis formation in breast cancer patients
H Wikman, K Lamszus, N Detels, L Uslar… - Breast Cancer …, 2012 - Springer
Introduction With the improvement of therapeutic options for the treatment of breast cancer,
the development of brain metastases has become a major limitation to life expectancy in …
the development of brain metastases has become a major limitation to life expectancy in …