The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

This is the first of two invited articles reviewing the development of nucleoside-analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

The ProTide technology is a prodrug approach developed for the efficient intracellular
delivery of nucleoside analogue monophosphates and monophosphonates. In this …

Acute kidney injury is a very common diagnosis, present in up to 60% of critical patients, and
its third main cause is drug toxicity. Nephrotoxicity can be defined as any renal injury caused …

Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …

HIV is a serious chronic medical condition. Significant improvements in antiretroviral therapy
have led to a transformation in its management. No curative treatment is available for HIV …

Phosphine oxides and related phosphorus-containing functional groups such as
phosphonates and phosphinates are established structural motifs that are still …

Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …