Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

The term epigenetics is defined as heritable changes in gene expression that are not due to
alterations of the DNA sequence. In the last years, it has become more and more evident …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

FOXA1 functions as a pioneer transcription factor by facilitating the access to chromatin for
steroid hormone receptors, such as androgen receptor and estrogen receptor,,–, but …

Alterations of genes regulating epigenetic processes are frequently found as cancer drivers
and may cause widespread alterations of DNA methylation, histone modification patterns, or …

The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …

Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …

Advancing the molecular knowledge surrounding fertility and inheritance has become
critical given the halving of sperm counts in the last 40 years, and the rise in complex …

It is well-established that Lysine-specific demethylase 1 (LSD1, also known as KDM1A)
roles as a lysine demethylase canonically acting on H3K4me1/2 and H3K9me1/2 for …

Background Deletion of the chromatin remodeler chromodomain helicase DNA-binding
protein 1 (CHD1) is a common genomic alteration found in human prostate cancers (PCas) …