The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the
cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible …

Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

Loss of RB1 gene is considered either a causal or an accelerating event in retinoblastoma.
A variety of mechanisms inactivates RB1 gene, including intragenic mutations, loss of …

p107 and p130 were originally identified as targets of the transforming domains of viral
oncoproteins encoded by small DNA tumor viruses. Together with pRB, the protein product …

The retinoblastoma tumor suppressor protein and its family members, p107 and p130, are
major regulators of the mammalian cell cycle. They exert their growth suppressive effects at …

It is well known that G1 to S phase transition is tightly regulated by the expression and
phosphorylation of a number of well‐characterized cyclins, cyclin‐dependent kinases and …

RB1 mutational inactivation is a cancer driver in various types of cancer including lung
cancer, making it an important target for therapeutic exploitation. We performed chemical …

Two genes, p107 and Rb2/p130, are strictly related to RB, the most investigated tumor
suppressor gene, responsible for susceptibility to retinoblastoma. The products of these …

Inactivation of the retinoblastoma tumor suppressor protein (pRB) contributes to
tumorigenesis in a wide variety of cancers. In contrast, the role of the two pRB-related …

The oncoprotein of simian virus-40, SV40 large T-antigen (Tag), is reported to target and to
inactivate growth suppressive proteins such as the retinoblastoma family1–3 and p53 (ref. 4 …