Some of the most significant leaps in the history of modern civilization—the development of
article in China, the steam engine, which led to the European industrial revolution, and the …

Recent discoveries in stem cell and developmental biology have introduced a new era
marked by the generation of in vitro models that recapitulate early mammalian development …

During embryogenesis, paracrine signaling between tissues in close proximity contributes to
the determination of their respective cell fate (s) and development into functional organs …

Tissue engineering approaches have the potential to increase the physiologic relevance of
human iPS-derived cells, such as cardiomyocytes (iPS-CM). However, forming Engineered …

Herein, we present an unconventional method for multimodal characterization of three-
dimensional cardiac organoids. This method can monitor and control the …

Abstract Three‐dimensional (3D) cultures of human pluripotent stem cell derived
cardiomyocytes (hPSC‐CMs) hold great promise for drug discovery, providing a better …

Cardiovascular diseases remain the leading cause of death worldwide; hence there is an
increasing focus on developing physiologically relevant in vitro cardiovascular tissue …

Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …

Multi-lineage development from gastruloids is enabling unprecedented opportunities to
model and study human embryonic processes and is expected to accelerate ex vivo …

Over the last decade, Organ-on-Chip (OoC) emerged as a promising technology for
advanced in vitro models, recapitulating key physiological cues. OoC approaches tailored …