Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury

QM Chen - Free Radical Biology and Medicine, 2022 - Elsevier
Myocardial infarction is the most common form of acute coronary syndrome. Blockage of a
coronary artery due to blood clotting leads to ischemia and subsequent cell death in the form …

Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting

M Sadrkhanloo, M Entezari, S Orouei, A Zabolian… - Life Sciences, 2022 - Elsevier
The nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of redox balance
and it responds to various cell stresses that oxidative stress is the most well-known one. The …

NO, CO and H2S: A trinacrium of bioactive gases in the brain

R Siracusa, VA Voltarelli, AT Salinaro… - Biochemical …, 2022 - Elsevier
Oxygen and carbon dioxide are time honored gases that have direct bearing on almost all
life forms, but over the past thirty years, and in large part due to the Nobel Prize Award in …

[HTML][HTML] Ferroptosis and its potential role in metabolic diseases: a curse or revitalization?

JY Duan, X Lin, F Xu, SK Shan, B Guo… - Frontiers in Cell and …, 2021 - frontiersin.org
Ferroptosis is classified as an iron-dependent form of regulated cell death (RCD) attributed
to the accumulation of lipid hydroperoxides and redox imbalance. In recent years …

[HTML][HTML] Protective effects of natural products against myocardial ischemia/reperfusion: Mitochondria-targeted therapeutics

X Su, M Zhou, Y Li, J Zhang, N An, F Yang… - Biomedicine & …, 2022 - Elsevier
Patients with ischemic heart disease receiving reperfusion therapy still need to face left
ventricular remodeling and heart failure after myocardial infarction. Reperfusion itself …

Farnesol Exerts Protective Effects against Chronic Sleep Deprivation‐Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult …

Y Li, Z Xie, X Luo, X Wang, Y Wang… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Sleep deprivation (SD) negatively affects all aspects of health, with one serious
consequence being impaired cognition. Farnesol (FOL) is a sesquiterpene synthesized by …

[HTML][HTML] Persulfidation of mitoKv7. 4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia/reperfusion injury

L Testai, R Montanaro, L Flori, E Pagnotta… - Biochemical …, 2023 - Elsevier
Abstract Background Hydrogen sulfide (H 2 S) is a gasotransmitter deeply involved in
cardiovascular homeostasis and implicated in the myocardial protection against …

[HTML][HTML] Verapamil alleviates myocardial ischemia/reperfusion injury by attenuating oxidative stress via activation of SIRT1

M Bao, W Huang, Y Zhao, X Fang, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Myocardial ischemia/reperfusion (I/R) injury is a potential complication of ischemic heart
disease after recanalization. One of the primary reasons for I/R injury is the excessive …

[HTML][HTML] Preclinical multi-target strategies for myocardial ischemia-reperfusion injury

Y Li, Y Gao, G Li - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Despite promising breakthroughs in diagnosing and treating acute coronary syndromes,
cardiovascular disease's high global mortality rate remains indisputable. Nearly half of these …

[HTML][HTML] TNF-α-Mediated endothelial cell apoptosis is rescued by hydrogen sulfide

L Diaz Sanchez, L Sanchez-Aranguren, K Wang… - Antioxidants, 2023 - mdpi.com
Highlights Hydrogen sulfide ameliorates TNF-α mediated endothelial dysfunction in human
endothelial cells by regulating the intrinsic apoptosis pathway. Beneficial effects of hydrogen …