Trained immunity: A “new” weapon in the fight against infectious diseases

A Dagenais, C Villalba-Guerrero, M Olivier - Frontiers in Immunology, 2023 - frontiersin.org
Innate immune cells can potentiate the response to reinfection through an innate form of
immunological memory known as trained immunity. The potential of this fast-acting …

Lyme disease and the pursuit of a clinical cure

H Adkison, ME Embers - Frontiers in Medicine, 2023 - frontiersin.org
Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-
borne illness in the United States. Many aspects of the disease are still topics of controversy …

Hitchhiker's Guide to Borrelia burgdorferi

JS Bourgeois, LT Hu - Journal of Bacteriology, 2024 - journals.asm.org
ABSTRACT Don't Panic. In the nearly 50 years since the discovery of Lyme disease, Borrelia
burgdorferi has emerged as an unlikely workhorse of microbiology. Interest in studying host …

Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation

T Petnicki-Ocwieja, JE McCarthy, U Powale… - Plos …, 2023 - journals.plos.org
Borrelia burgdorferi (Bb), the causative agent of Lyme disease, establishes a long-term
infection and leads to disease manifestations that are the result of host immune responses to …

Cellular and transcriptome signatures unveiled by single-cell RNA-Seq following ex vivo infection of murine splenocytes with Borrelia burgdorferi

V Kumaresan, TMM Ingle, N Kilgore, G Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Lyme disease, the most common tick-borne infectious disease in the US, is
caused by a spirochetal pathogen Borrelia burgdorferi (Bb). Distinct host responses are …

[HTML][HTML] Netosis and trained immunity in tick-borne diseases: A possible pathogenetic role

GD Badami, B Tamburini, L Mohammadnezhad… - Cellular …, 2024 - Elsevier
Various types of pathogens transmitted by ticks elicit distinct immune responses just like the
emerging α-Gal syndrome that is associated with allergic reactions to tick bites. The …

Animal Models of Lyme Carditis. Understanding How to Study a Complex Disease

S Maher, L Scott, S Zhang, A Baranchuk - Current Problems in Cardiology, 2024 - Elsevier
Lyme carditis, a well-established manifestation of Lyme disease, has been studied in animal
models to improve understanding of its pathogenesis. This review synthesizes existing …

Etiopathogenesis of Lyme Carditis

OHI Chou, K Hui, VHC Chou, A Baranchuk… - Lyme Carditis: From A to …, 2023 - Springer
The development of Lyme carditis is largely mediated by the direct invasion of the
myocardial tissue and the subsequent triggering of pro-inflammatory changes. Borrelia spp …

[引用][C] Editorial commentary: Lyme carditis-" a ray of light revealed in a dark story" of dilated cardiomyopathy.

S Momčilović, A Jovanović - Trends in Cardiovascular Medicine, 2022 - europepmc.org
Editorial commentary: Lyme carditis - "a ray of light revealed in a dark story" of dilated
cardiomyopathy. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe …