We are experiencing rapid progress in all types of imaging techniques used in the detection
of various numbers and types of mutation. In situ hybridization (ISH) is the primary technique …

Detection of biomolecules in tissues provides contextual information and the possibility to
assess the interaction of different cell types and markers. Routine qualitative assessment of …

Predicting the best treatment strategy from genomic information is a core goal of precision
medicine. Here we focus on predicting drug response based on a cohort of genomic …

The Notch signaling pathway is a fundamental signaling mechanism operating in most, if not
all, multicellular organisms and in most cell types in the body. Like other" ivy league" …

Effective treatment of patients with triple-negative (ER-negative, PR-negative, HER2-
negative) breast cancer remains a challenge. Although PARP inhibitors are being evaluated …

Bifidobacterium spp. are abundant gut commensals, especially in breast-fed infants.
Bifidobacteria are associated with many health-promoting effects including maintenance of …

Fanconi anemia hematopoietic stem cells display poor self-renewal capacity when
subjected to a variety of cellular stress. This phenotype raises the question of whether the …

The screening of living cells using high-throughput microarrays is technically challenging.
Great care must be taken in the chemical presentation of potential ligands and the number of …

Overview Cancers are complex, adaptive systems comprised of cancer cells that are
influenced by supporting cells, immune cells, as well as soluble and insoluble proteins that …

The thesis addresses the impact of androgen deprivation in combination with gene functions
in prostate cancer (PCa), as well as the development of ex vivo cancer models. The studies …