Estrogen receptor function: impact on the human endometrium

K Yu, ZY Huang, XL Xu, J Li, XW Fu… - Frontiers in …, 2022 - frontiersin.org
The physiological role of estrogen in the female endometrium is well established. On the
basis of responses to steroid hormones (progesterone, androgen, and estrogen), the …

Uterine bleeding: how understanding endometrial physiology underpins menstrual health

V Jain, RR Chodankar, JA Maybin… - Nature reviews …, 2022 - nature.com
Menstruation is a physiological process that is typically uncomplicated. However, up to one
third of women globally will be affected by abnormal uterine bleeding (AUB) at some point in …

Estrogens in male physiology

PS Cooke, MK Nanjappa, CM Ko… - Physiological …, 2017 - journals.physiology.org
Estrogens have historically been associated with female reproduction, but work over the last
two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) …

Critical role of estrogens on bone homeostasis in both male and female: from physiology to medical implications

E Noirrit-Esclassan, MC Valera, F Tremollieres… - International Journal of …, 2021 - mdpi.com
Bone is a multi-skilled tissue, protecting major organs, regulating calcium phosphate
balance and producing hormones. Its development during childhood determines height and …

Sex-based differences in skeletal muscle kinetics and fiber-type composition

KM Haizlip, BC Harrison, LA Leinwand - Physiology, 2015 - journals.physiology.org
Previous studies have identified over 3,000 genes that are differentially expressed in male
and female skeletal muscle. Here, we review the sex-based differences in skeletal muscle …

Estrogen synthesis and signaling pathways during aging: from periphery to brain

J Cui, Y Shen, R Li - Trends in molecular medicine, 2013 - cell.com
Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

Estrogen hormone biology

KJ Hamilton, SC Hewitt, Y Arao, KS Korach - Current topics in …, 2017 - Elsevier
The hormone estrogen is involved in both female and male reproduction, as well as
numerous other biological systems including the neuroendocrine, vascular, skeletal, and …

Estrogen receptor null mice: what have we learned and where will they lead us?

JF Couse, KS Korach - Endocrine reviews, 1999 - academic.oup.com
Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

Human skin pigmentation: melanocytes modulate skin color in response to stress

GE Costin, VJ Hearing - The FASEB journal, 2007 - Wiley Online Library
All organisms, from simple invertebrates to complex human beings, exist in different colors
and patterns, which arise from the unique distribution of pigments throughout the body …

Generation and reproductive phenotypes of mice lacking estrogen receptor β

JH Krege, JB Hodgin, JF Couse… - Proceedings of the …, 1998 - National Acad Sciences
Estrogens influence the differentiation and maintenance of reproductive tissues and affect
lipid metabolism and bone remodeling. Two estrogen receptors (ERs) have been identified …