Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

Lipoxygenase reactions may initiate the synthesis of a signaling molecule or be involved in
inducing structural or metabolic changes in the cell. For signaling, synthesis of a single fatty …

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent nuclear
receptor that has been implicated in the modulation of critical aspects of development and …

Atherosclerosis may be viewed as an inflammatory disease process that includes early
oxidative modification of LDLs, leading to foam cell formation. This “oxidation hypothesis” …

Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

Here we report the first structure of a mammalian 15-lipoxygenase. The protein is composed
of two domains; a catalytic domain and a previously unrecognized β-barrel domain. The N …

Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of
polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12 …

The family of transcription factors termed peroxisome proliferator-activated receptors
(PPARs) has recently been the focus of much interest for their possible role in the regulation …

Peroxisome proliferator‐activated receptor (PPAR) s are a family of three nuclear hormone
receptors, PPARα,‐δ, and‐γ, which are members of the steriod receptor superfamily. The …

Haptoglobin is a positive acute phase protein that binds free hemoglobin and removes it
from the circulation to prevent kidney injury and iron loss following hemolysis. Also, by …