Therapeutic developments in pancreatic cancer

ZI Hu, EM O'Reilly - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most
lethal human malignancies. Much is known regarding the biology and pathophysiology of …

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

JML Ostrem, KM Shokat - Nature reviews Drug discovery, 2016 - nature.com
KRAS is the most frequently mutated oncogene in human cancer. In addition to holding this
distinction, unsuccessful attempts to target this protein have led to the characterization of …

Ras conformational ensembles, allostery, and signaling

S Lu, H Jang, S Muratcioglu, A Gursoy, O Keskin… - Chemical …, 2016 - ACS Publications
Ras proteins are classical members of small GTPases that function as molecular switches by
alternating between inactive GDP-bound and active GTP-bound states. Ras activation is …

RAS oncogenes: the first 30 years

M Malumbres, M Barbacid - Nature Reviews Cancer, 2003 - nature.com
From the pioneering work with acute transforming retroviruses to the current post-genomic
era, RAS genes have always been at the leading edge of signal transduction and molecular …

Targeting KRAS in pancreatic cancer: new drugs on the horizon

SF Bannoura, MH Uddin, M Nagasaka, F Fazili… - Cancer and Metastasis …, 2021 - Springer
Abstract Kirsten Rat Sarcoma (KRAS) is a master oncogene involved in cellular proliferation
and survival and is the most commonly mutated oncogene in all cancers. Activating KRAS …

The Ras protein superfamily: evolutionary tree and role of conserved amino acids

AM Rojas, G Fuentes, A Rausell, A Valencia - Journal of Cell Biology, 2012 - rupress.org
The Ras superfamily is a fascinating example of functional diversification in the context of a
preserved structural framework and a prototypic GTP binding site. Thanks to the availability …

Structural basis of biological nitrogen fixation

JB Howard, DC Rees - Chemical reviews, 1996 - ACS Publications
During the past century, chemists have sought economical methods of fixing atmospheric
dinitrogen for use as fertilizer, explosives, and other chemicals. Despite the simplicity of the …

G protein mechanisms: insights from structural analysis

SR Sprang - Annual review of biochemistry, 1997 - annualreviews.org
This review is concerned with the structures and mechanisms of a superfamily of regulatory
GTP hydrolases (G proteins). G proteins include Ras and its close homologs, translation …

Crystal structure of the bacterial cell-division protein FtsZ

J Löwe, LA Amos - Nature, 1998 - nature.com
Bacterial cell division ends with septation, the constriction of the cell wall and cell
membranes that leads to the formation of two daughter cells,. During septation, FtsZ, a …

G-protein signaling: back to the future

CR McCudden, MD Hains, RJ Kimple… - Cellular and molecular …, 2005 - Springer
Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …