SLC6 neurotransmitter transporters: structure, function, and regulation
AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
Regulation of the dopamine and vesicular monoamine transporters: pharmacological targets and implications for disease
CL German, MG Baladi, LM McFadden… - Pharmacological …, 2015 - ASPET
Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …
The solute carrier 6 family of transporters
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy
LC Daws - Pharmacology & therapeutics, 2009 - Elsevier
Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and
DAT respectively), are the key players terminating transmission of these amines in the …
DAT respectively), are the key players terminating transmission of these amines in the …
Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters
B Haenisch, H Bönisch - Pharmacology & therapeutics, 2011 - Elsevier
Major depressive disorder (MDD) which is supposed to result from a complex interaction of
genetic and epigenetic, environmental and developmental factors is one of the most …
genetic and epigenetic, environmental and developmental factors is one of the most …
Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors
Cocaine exerts its stimulatory effect by inhibiting the dopamine transporter (DAT). However,
novel benztropine-and rimcazole-based inhibitors show reduced stimulant effects compared …
novel benztropine-and rimcazole-based inhibitors show reduced stimulant effects compared …
Dopamine transporter-related effects of modafinil in rhesus monkeys
ML Andersen, E Kessler, KS Murnane, JC McClung… - …, 2010 - Springer
Rationale Modafinil is currently used as a treatment for daytime sleepiness. Objectives The
objectives of this study were to explore the dopamine transporter (DAT)-related effects of …
objectives of this study were to explore the dopamine transporter (DAT)-related effects of …
Interaction of cocaine‐, benztropine‐, and GBR12909‐like compounds with wild‐type and mutant human dopamine transporters: molecular features that differentially …
The widely abused psychostimulant cocaine is thought to elicit its reinforcing effects
primarily via inhibition of the neuronal dopamine transporter (DAT). However, not all DAT …
primarily via inhibition of the neuronal dopamine transporter (DAT). However, not all DAT …
The binding sites for benztropines and dopamine in the dopamine transporter overlap
H Bisgaard, MAB Larsen, S Mazier, T Beuming… - …, 2011 - Elsevier
Analogs of benztropines (BZTs) are potent inhibitors of the dopamine transporter (DAT) but
are less effective than cocaine as behavioral stimulants. As a result, there have been efforts …
are less effective than cocaine as behavioral stimulants. As a result, there have been efforts …
Comparative modeling of the human monoamine transporters: similarities in substrate binding
The amino acid compositions of the substrate binding pockets of the three human
monoamine transporters are compared as is the orientation of the endogenous substrates …
monoamine transporters are compared as is the orientation of the endogenous substrates …