Current management of locally advanced rectal cancer achieves high cure rates, distant
metastatic spread being the main cause of patients' death. Total neoadjuvant therapy (TNT) …

The ability to experience pleasurable sexual activity is important for human health.
Receptive anal intercourse (RAI) is a common, though frequently stigmatized, pleasurable …

Importance In March 2023, the National Comprehensive Cancer Network endorsed watch
and wait for those with complete clinical response to total neoadjuvant therapy. Neoadjuvant …

Overall survival benefit of total neoadjuvant treatment (TNT) remains unconfirmed. Thus, in
our opinion, the main rationale for using TNT is a planned watch-and-wait (w&w) strategy to …

Simple Summary Organ preservation strategies can be offered to patients with rectal cancer
that show a strong response to preoperative treatment in order to avoid major surgery …

Background Potential differences in organ preservation between total neoadjuvant therapy
(TNT) regimens integrating long-course chemoradiotherapy (LCCRT) and short-course …

Background We hypothesise that a high rate of tumour regrowth after the watch-and-wait
(w&w) strategy may lead, despite salvage surgery, to a significant impairment of ultimate …

Aim A complete or subcomplete tumour response (CTR) is observed in 10%–25% of
patients with mid/low rectal cancer after neoadjuvant chemoradiotherapy (CRT). The aim of …

This article adopts a multidisciplinary approach, including surgery, oncology, radiology and
patient perspectives, to discuss the key points of debate surrounding a watch and wait …

Introduction Standard treatment for patients with intermediate or locally advanced rectal
cancer is (chemo) radiotherapy followed by total mesorectal excision (TME) surgery. In …