Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Epilepsy, antiepileptic drugs, and aggression: an evidence-based review

MJ Brodie, F Besag, AB Ettinger, M Mula, G Gobbi… - Pharmacological …, 2016 - ASPET
Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

Deep brain activities can be detected with magnetoencephalography

F Pizzo, N Roehri, S Medina Villalon… - Nature …, 2019 - nature.com
The hippocampus and amygdala are key brain structures of the medial temporal lobe,
involved in cognitive and emotional processes as well as pathological states such as …

Altered functional connectivity and small-world in mesial temporal lobe epilepsy

W Liao, Z Zhang, Z Pan, D Mantini, J Ding, X Duan… - PloS one, 2010 - journals.plos.org
Background The functional architecture of the human brain has been extensively described
in terms of functional connectivity networks, detected from the low–frequency coherent …

Impaired consciousness in epilepsy

H Blumenfeld - The Lancet Neurology, 2012 - thelancet.com
Consciousness is essential to normal human life. In epileptic seizures consciousness is
often transiently lost, which makes it impossible for the individual to experience or respond …

Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain

J Gotman, C Grova, A Bagshaw… - Proceedings of the …, 2005 - National Acad Sciences
Our objective was to evaluate the brain regions showing increased and decreased
metabolism in patients at the time of generalized bursts of epileptic discharges in order to …

Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures

H Blumenfeld, GI Varghese, MJ Purcaro, JE Motelow… - Brain, 2009 - academic.oup.com
Generalized tonic–clonic seizures are among the most dramatic physiological events in the
nervous system. The brain regions involved during partial seizures with secondary …

Cerebellar directed optogenetic intervention inhibits spontaneous hippocampal seizures in a mouse model of temporal lobe epilepsy

E Krook-Magnuson, GG Szabo, C Armstrong, M Oijala… - eneuro, 2014 - eneuro.org
Abstract Cover Figure Krook-Magnuson et al. report a bidirectional functional connectivity
between the hippocampus and the cerebellum in a mouse model of temporal lobe epilepsy …

Positive and negative network correlations in temporal lobe epilepsy

H Blumenfeld, KA McNally, SD Vanderhill… - Cerebral …, 2004 - academic.oup.com
Temporal lobe seizures are accompanied by complex behavioral phenomena including loss
of consciousness, dystonic movements and neuroendocrine changes. These phenomena …

Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference

F Xiao, L Caciagli, B Wandschneider, D Sone… - Brain, 2023 - academic.oup.com
Artificial intelligence (AI)-based tools are widely employed, but their use for diagnosis and
prognosis of neurological disorders is still evolving. Here we analyse a cross-sectional …