The neural substrates of higher-order conditioning: A review

NM Holmes, JP Fam, KJ Clemens, V Laurent… - Neuroscience & …, 2022 - Elsevier
Sensory preconditioned and second-order conditioned responding are each well-
documented. The former occurs in subjects (typically rats) exposed to pairings of two …

The basolateral amygdala: The core of a network for threat conditioning, extinction, and second-order threat conditioning

T Sepahvand, KD Power, T Qin, Q Yuan - Biology, 2023 - mdpi.com
Simple Summary Threat conditioning is a process by which animals learn about danger. As
such, this process has been extensively studied as a model of how humans develop fears …

Parabrachial Calca neurons mediate second-order conditioning

S Park, A Zhu, F Cao, RD Palmiter - Nature Communications, 2024 - nature.com
Learning to associate cues, both directly and indirectly, with biologically significant events is
essential for survival. Second-order conditioning (SOC) involves forming an association …

'Online'integration of sensory and fear memories in the rat medial temporal lobe

FS Wong, RF Westbrook, NM Holmes - elife, 2019 - elifesciences.org
How does a stimulus never associated with danger become frightening? The present study
addressed this question using a sensory preconditioning task with rats. In this task, rats …

The role of the basolateral amygdala and infralimbic cortex in (re) learning extinction

NW Lingawi, V Laurent, RF Westbrook… - Psychopharmacology, 2019 - Springer
The basolateral amygdala complex (BLA) and infralimbic region of the prefrontal cortex (IL)
play distinct roles in the extinction of Pavlovian conditioned fear in laboratory rodents. In the …

Understanding associative learning through higher-order conditioning

D Gostolupce, BPP Lay, EJP Maes… - Frontiers in Behavioral …, 2022 - frontiersin.org
Associative learning is often considered to require the physical presence of stimuli in the
environment in order for them to be linked. This, however, is not a necessary condition for …

Prediction error determines whether NMDA receptors in the basolateral amygdala complex are involved in Pavlovian fear conditioning

MJ Williams-Spooner, AJ Delaney… - Journal of …, 2022 - Soc Neuroscience
It is widely accepted that activation of NMDA receptors (NMDAR) is necessary for the
formation of fear memories in the basolateral amygdala complex (BLA). This acceptance is …

Context and time regulate fear memory consolidation and reconsolidation in the basolateral amygdala complex

J Leake, LS Cardona, F Mencevski… - Journal of …, 2024 - Soc Neuroscience
It is widely accepted that fear memories are consolidated through protein synthesis-
dependent changes in the basolateral amygdala complex (BLA). However, recent studies …

Danger changes the way the brain consolidates neutral information; and does so by interacting with processes involved in the encoding of that information

OA Qureshi, J Leake, AJ Delaney… - Journal of …, 2023 - Soc Neuroscience
This study examined the effect of danger on consolidation of neutral information in two
regions of the rat (male and female) medial temporal lobe: the perirhinal cortex (PRh) and …

The conditions under which consolidation of serial-order conditioned fear requires de novo protein synthesis in the basolateral amygdala complex

MJ Williams-Spooner, RF Westbrook… - Journal of …, 2019 - Soc Neuroscience
Consolidation of conditioned fear to a stimulus (S1) paired with shock requires de novo
protein synthesis in the basolateral amygdala complex (BLA), whereas consolidation of …