This review considers computational psychiatry from a particular viewpoint: namely, a
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …

Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …

ABSTRACT Background Patients with Parkinson's disease (PD) often develop dementia, but
the underlying substrate is incompletely understood. Generalized synaptic degeneration …

Abstract Background Patients with Lewy body diseases exhibit variable degrees of cortical
and subcortical hypometabolism. However, the underlying causes behind this progressive …

Clinical trials in dementia with Lewy bodies: the evolving c... : Current Opinion in Neurology
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient …

Synaptic dysfunction and altered synaptic pruning are present in people with Parkinsonian
disorders. Dopamine loss and alpha‐synuclein accumulation, two hallmarks of Parkinson's …

Parkinson's disease (PD) and other neurodegenerative parkinsonisms are characterised by
loss of striatal dopaminergic neurons. Dopamine functional deficits can be measured in vivo …

Parkinson's disease (PD) is caused by progressive neurodegeneration and characterised by
motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations …

Synaptic loss occurs early in many neurodegenerative diseases and contributes to cognitive
impairment even in the absence of gross atrophy. Currently, for human disease there are …